Goff, Lions Favored on Road Against Brissett's Cardinals
The Detroit Lions travel to face the Arizona Cardinals on Sunday, October 11, 2026, with kickoff set for 4:25 p.m. ET at State Farm Stadium in Glendale, Arizona. Both teams enter coming off losses from October 4: Arizona fell 36-24 to the Giants, while Detroit dropped a 32-26 decision at Carolina.
The Cardinals sit at 1-3 through four games. Jacoby Brissett has thrown for 818 yards with six touchdowns and four interceptions, three of which came in the loss to the Giants, when he completed 21 of 35 passes for 166 yards. Arizona's passing offense ranks 22nd in the league at 194.3 yards per game, with tight end Trey McBride serving as the primary target - he has drawn at least 10 looks in every outing, totaling 33 catches for 242 yards and two touchdowns. Arizona's defense has allowed 117 points this season, an average of 29.3 per game. bet on biathlon games
Detroit brings the NFL's third-ranked passing attack at 287.3 yards per game, powered by Jared Goff's 1,214 yards, nine touchdowns and zero interceptions through four contests. Goff threw for 412 yards against Carolina on 32-of-52 passing. Tight end Sam LaPorta has emerged as a key target, catching 22 passes for 228 yards and two touchdowns, including an eight-catch, 84-yard, one-touchdown performance at Carolina. The Lions' defense, however, has struggled, surrendering 127 points - 31.8 per game. Both teams share a plus-3 turnover margin, tied for fourth in the NFL.
Detroit enters as a 5.5-point favorite, with the game total set at 53.5 points. The moneyline favors the Lions at -253, with the Cardinals priced at +208. Arizona's defensive struggles against a Detroit passing game operating at a high level will be a central factor, as will whether Brissett can protect the ball after his turnover-heavy outing against the Giants.
